RESUMEN
BACKGROUND: Oral cancer (OC) is a multifactorial disease that affects the oral cavity. The mortality rate is approximately 50 % and a high percentage of patients are diagnosed in advanced stages. Early diagnosis has been well demonstrated to improve overall survival, mainly when detected at a localized stage. Non-invasive techniques can help identify malignant features in real time, thus improving the path to diagnosis. This study aimed to perform a bibliometric analysis of the top 100 articles cited on diagnostic aids for oral cancer. METHODS: Articles from 2000 to 2023 in Scopus were scanned using five OC topic titles crossed with 27 diagnostic aid keywords. Duplicate manuscripts were eliminated using Microsoft Excel software and publications were ranked according to their citation count. This study selected and analyzed the top 100 most cited English-language papers. RESULTS: 86,676 citations were accumulated by the top 100 articles most cited. 2011 was the year with the highest number of publications with OC papers. The article with the most citations obtained a total of 30,832. The United States was the country with the most publications, with a total of 45, and UCLA was the institution with the most publications (7) among the top 100 most cited papers. CONCLUSIONS: This study identified the top 100 most cited articles on diagnostic aids for oral cancer. These results can help dentists, specialists, healthcare providers, and researchers become familiar with the most influential publications in this field.
RESUMEN
Ozone (O3) is a reactive oxygen species (ROS) that can interact with cellular components and cause oxidative stress. Following said logic, if O3 induces such a stressful milieu, how does it exert antioxidant functions? This is mediated by controlled toxicity produced by low concentrations of O3, which enhance the cell's suppliance of antioxidant properties without causing any further damage. Therapeutic concentrations vary extensively, although 50 µg/mL is commonly used in experimental and clinical procedures, given that augmented concentrations might work as germicides or cause endogenous damage. O3 therapy has been shown to be effective when applied before or after traumatic renal procedures, whether caused by ischemia, xenobiotics, chronic damage, or other models. In this review, we focus on discussing the role of O3 therapy in different models of kidney damage associated with fibrosis, apoptosis, oxidative stress, and inflammation. We integrate and report knowledge about O3 in renal therapy, debunking skepticism towards unconventional medicine, explaining its proven therapeutic properties, and thus providing background for its use in further research as well as in clinical settings.
